Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay
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چکیده
منابع مشابه
DNA Repair Measured by the Comet Assay
The stability of the genome is of crucial importance, and yet the DNA molecule is prone to spontaneous loss of bases, and damage from exogenous and endogenous sources – with potentially mutagenic consequences. Damage can take the form of small alterations to bases (alkylation or oxidation); breaks in the sugar-phosphate backbone involving one or both strands (single or double strand breaks – SS...
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The alkylating mutagens N-methyl-N-nitrosourea (MNU) and methyl methanesulfonate (MMS) were studied for their potential to induce DNA strand breaks and abasic (AP) sites in meristematic nuclei of Vicia faba root tips by the comet assay. The alkaline unwinding/neutral electrophoresis (A/N) and alkaline unwinding/alkaline electrophoresis (A/A) protocols were used for detection of DNA damage. With...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2001
ISSN: 1464-3804
DOI: 10.1093/mutage/16.5.439